Which symptom is a hallmark of caffeine withdrawal?

Which symptom is a hallmark of caffeine withdrawal?

• A. Headache
• B. Hyperactivity
• C. Euphoria
• D. Weight gain

Answer: (A)

Caffeine withdrawal produces a rebound increase in adenosine activity after stopping caffeine, which causes cerebral vasodilation and a throbbing headache. This headache is the best-known sign because it directly reflects the vascular changes that occur when the stimulant’s effects wear off. It typically appears within a day of last use and can last several days, often peaking early. While fatigue, irritability, and difficulty concentrating may also occur, the headache stands out as the most characteristic feature. Hyperactivity, euphoria, and weight gain do not fit the withdrawal pattern.

Caffeine withdrawal produces a rebound increase in adenosine activity after stopping caffeine, which causes cerebral vasodilation and a throbbing headache. This headache is the best-known sign because it directly reflects the vascular changes that occur when the stimulant’s effects wear off. It typically appears within a day of last use and can last several days, often peaking early. While fatigue, irritability, and difficulty concentrating may also occur, the headache stands out as the most characteristic feature. Hyperactivity, euphoria, and weight gain do not fit the withdrawal pattern.