Suboxone is the combination of which medications?

Suboxone is the combination of which medications?

• A. Buprenorphine and naloxone
• B. Methadone and buprenorphine
• C. Naltrexone and buprenorphine
• D. Methadone and naloxone

Answer: (A)

Suboxone combines a partial opioid agonist with an antagonist to both suppress withdrawal and curb misuse. Buprenorphine provides enough receptor activity to relieve cravings and withdrawal but has a ceiling effect, reducing overdose risk. Naloxone is added to deter injection misuse: when Suboxone is taken as prescribed, naloxone has little effect because it’s poorly absorbed orally or sublingually; if someone tries to inject, naloxone becomes active and can precipitate withdrawal, discouraging misuse. This specific pairing—buprenorphine with naloxone—is what defines Suboxone. Subutex contains buprenorphine alone without naloxone.

Suboxone combines a partial opioid agonist with an antagonist to both suppress withdrawal and curb misuse. Buprenorphine provides enough receptor activity to relieve cravings and withdrawal but has a ceiling effect, reducing overdose risk. Naloxone is added to deter injection misuse: when Suboxone is taken as prescribed, naloxone has little effect because it’s poorly absorbed orally or sublingually; if someone tries to inject, naloxone becomes active and can precipitate withdrawal, discouraging misuse. This specific pairing—buprenorphine with naloxone—is what defines Suboxone. Subutex contains buprenorphine alone without naloxone.